Fundamentals Of Toxicology

Autor: PK Gupta
Publisher: Academic Press
ISBN: 0128054034
File Size: 46,79 MB
Format: PDF, ePub
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Fundamentals of Toxicology: Essential Concepts and Applications provides a crisp, easy-to-understand overview of the most important concepts, applications, and ideas needed to learn the basics of toxicology. Written by a pre-eminent toxicologist with over five decades of teaching experience, this comprehensive resource offers the hands-on knowledge needed for a strong foundation in the wide field of toxicology. Fundamentals of Toxicology includes a clear structure divided into five units to assist learning and understanding. The first unit provides extensive coverage on the background of toxicology including commonly used definitions and historical perspective, while following units cover: basic concepts; regulatory requirements and good laboratory practices, including types of toxicology testing and evaluation; toxic agents and adverse effects on health; and analytical, forensic, and diagnostic toxicology. This is an essential book for advanced students in toxicology and across the biomedical sciences, life sciences, and environmental sciences who want to learn the concepts of toxicology, as well as early researchers needing to refresh outside of their specialty. Explains the essential concepts of toxicology in a clear fashion Provides in-depth coverage of testing protocols, common drugs, chemicals, and laboratory-based diagnostic and analytical toxicology Explores the history, foundations, and most recent concepts of toxicology Serves as an essential reference for advanced students in toxicology and across the biomedical, life, and environmental sciences who want to learn the concepts of toxicology

Fundamentals Of Analytical Toxicology

Autor: Robert J. Flanagan
Publisher: John Wiley & Sons
ISBN: 0470516283
File Size: 77,24 MB
Format: PDF, ePub, Mobi
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The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens. After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electrophoresis, mass spectrometry, and immunoassay – are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites. Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. Praise from the reviews: “This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.” Review from Randall Baselt "This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists “Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background “Boxes”. The many and up to date literature references in each chapter demonstrate the authors’ thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.” GTFCh Bulletin “Toxichem + Krimtech”, May 2008 (translated, original review in German) “Many toxicologists will add this important reference to their libraries because it competently fills a need ...” International Journal of Toxicology

Principles Of Toxicology Third Edition

Autor: Karen E. Stine
Publisher: CRC Press
ISBN: 1466503432
File Size: 63,62 MB
Format: PDF
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Reflecting the broad and interdisciplinary nature of toxicology, this third edition of Principles of Toxicology explores the biochemical, physiological, and environmental aspects of the subject. This new edition is updated and revised to include reference to several major new directions in the science of toxicology, including significant changes in thinking about cancer and carcinogenesis as well as the rapid expansion of toxicogenomics. The book also includes new chapters on topics of timely interest such as radiation, food safety, and natural toxins. As in previous editions, chapters combine background material in the appropriate discipline—which helps readers review and remember the basics—with new information on toxicology to stress key principles and concepts. Also included is a selection of updated case studies through which principles and concepts are applied to real-world issues. The book features an extensive cross-referencing system linking all sections and enhancing the integration of material, thus helping readers tie it all together. It also includes an appendix of selected toxicants that describes chemical structure, category of use, and toxicity. These features make specific information quick and easy to find. The easy-to-follow format and clear presentation of information in this book will make this one of the most useful references on your shelf.

Fundamentals Of Aquatic Toxicology

Autor: Gary M. Rand
Publisher: CRC Press
ISBN: 9781560320906
File Size: 25,18 MB
Format: PDF, Docs
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This text is divided into three parts. The first part describes basic toxicological concepts and methodologies used in aquatic toxicity testing, including the philosophies underlying testing strategies now required to meet and support regulatory standards. The second part of the book discusses various factors that affect transport, transformation, ultimate distribution, and accumulation of chemicals in the aquatic environment, along with the use of modelling to predict fate.; The final section of the book reviews types of effects or endpoints evaluated in field studies and the use of structure-activity relationships in aquatic toxicology to predict biological activity and physio-chemical properties of a chemical. This section also contains an extensive background of environmental legislation in the USA and within the European Community, and an introduction to hazard/risk assessment with case studies.

Principles Of Toxicology Testing Second Edition

Autor: Frank A Barile
Publisher: CRC Press
ISBN: 1842145290
File Size: 37,68 MB
Format: PDF, ePub, Docs
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Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.

Fundamental Toxicology And Risk Assessment

Autor: Natl Env Hlth
Publisher: CRC Press
ISBN: 9780873716413
File Size: 29,98 MB
Format: PDF, Mobi
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Fundamental Toxicology and Risk Assessment is a computer-based training (CBT) program developed through the National Environmental Health Association (NEHA). It is geared toward individuals with little or no background in toxicology and risk assessment and has been used successfully as a course supplement at several universities, including the University of California at Riverside and Bowling Green State University. Computer-based training is a superior method for basic training in toxicology and risk assessment because it is individualized, self-paced, easy to update, and cost effective. It also produces immediate results and is easily accessible for refresher training. It eliminates the expense and difficulty of obtaining instructors and scheduling class time. Fundamental Toxicology and Risk Assessment utilizes colorful, animated graphics to make learning easy and fun. Fundamental Toxicology and Risk Assessment is an excellent instructional tool for remedial program managers, emergency responders, on-scene coordinators, risk communicators, community relations specialists, permit writers, and others who need to understand the fundamentals of toxicology and risk assessment. Hardware Requirements This CBT program has been specifically designed to operate on an IBM or IBM-compatible computer with at least an 80286 microprocessor (AT-type machine). Although it will operate on the slower 8088 microprocessor (XT-type) microprocessor, the execution of its animated graphic sequences will not be optimal at that speed. An EGA or VGA graphics card and monitor are required to operate the program, as well as a hard disk with at least 4.5 megabytes of free space.

Fundamentals Of Toxicologic Pathology

Autor: Wanda M. Haschek
Publisher: Academic Press
ISBN: 9780080919324
File Size: 66,62 MB
Format: PDF, Docs
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Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology Second Edition updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists. 25% brand new information, fully revised throughout New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology New color photomicrographs detailing specific toxicant-induced diseases in animals Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels

Lu S Basic Toxicology

Autor: Byung-Mu Lee
Publisher: CRC Press
ISBN: 1841849545
File Size: 42,44 MB
Format: PDF, ePub
Read: 9503
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This new edition of our bestselling book, Lu’s Basic Toxicology, provides a number of key benefits that make it a must-read for toxicology specialists worldwide, including: Revision of a Bestseller - the new Sixth Edition provides the critical updates toxicologists need to keep up with the changing times New Information - on over-the-counter preparations, lactation, and occupational toxicology, providing clarity and insight into a rapidly evolving subject Comprehensive - Updated, topical additions - new chapters on Nanotoxicology and Toxicity of Endocrine System provide you with information not currently available elsewhere Expert Editors - Kacew & Lee offers a distillation of decades and research and teaching experience in toxicology, providing authoritative guidance for both students and practicing professionals Practical- Easy to read information at your fingertips - In-depth, yet concise presentation of material – split into four key sections that include separate subject and chemical indexes all while in the 6 x 9 format makes this a useful, quick pocket-guide for the more experienced researcher.