Comparative Pharmacokinetics

Autor: Jim E. Riviere
Publisher: John Wiley & Sons
ISBN: 9780470959886
File Size: 32,79 MB
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Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.

Handbook Of Comparative Pharmacokinetics And Residues Of Veterinary Therapeutic Drugs

Autor: Arthur L. Craigmill
Publisher: CRC Press
ISBN: 1351089374
File Size: 38,89 MB
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Handbook of Comparative Pharmacokinetics and Residues of Veterinary Therapeutic Drugs is a unique compilation of comparative pharmacokinetic data for veterinary therapeutic drugs. The book features an excellent introductory chapter on basic veterinary pharmacokinetics and includes pharmacological data taken from hundreds of primary research references. These data are presented in standardized units and are arranged in conveniently organized tables so that comparisons between data can be made easily. Much of the data is new and was taken from articles in which data was not subjected to pharmacokinetic analysis.

Handbook Of Comparative Pharmacokinetics And Residues Of Veterinary Antimicrobials

Autor: Jim E Riviere
Publisher: CRC Press
ISBN: 1351087959
File Size: 32,24 MB
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The major objective of this handbook is to compile-in tabular form-the pharmacokinetic parameters of antimicrobial drugs used in food animals. This unique publication represents data from the FARAD (Food Animal Residue Avoidance Databank) databank, established by the authors under the auspices of the U.S.D.A. and contains significant amounts of previously unavailable information. This updated, one-of-a-kind volume even features additional data on laboratory rodents, dogs, cats, and horses in order to facilitate broader interspecies extrapolations. This easy-to-use reference is timely as well as invaluable to animal scientists, veterinarians, pharmacologists, and toxicologists who work with antimicrobials in chickens, turkeys, dairy and beef cattle, swine, goats, and sheep.

Comparative Pharmacokinetics Of Matrine

Autor: Guanghua Gao
File Size: 40,29 MB
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Acapha®, an herbal product used for treating esophageal cancer in China, is undergoing clinical trials as a chemopreventive agent for lung cancer at the B.C. Cancer Agency (BCCA). Little is known of the pharmacokinetics (PK) of Acapha® because most of the PK tools available today are developed for a single chemical entity not a chemical mixture such as Acapha®. The purposes of the present study were to demonstrate the feasibility of using matrine as a chemical marker to study the PK of Acapha®, to compare the PK of pure matrine with the PK of crude matrine in Acapha®, to elucidate the underlying mechanism of matrine absorption and metabolism, and to develop and validate a physiologically based pharmacokinetic (PBPK) model of matrine for rats and humans. A generic matrine PBPK model consisting of 12 compartments was developed and validated in the rat. The rat model was then scaled to the model of a standard human by replacing the parameters in the rat model with those of humans. The human PBPK model was able to describe closely the time course of matrine concentrations in plasma (or urine) reported in the literature or from a human study at the BCCA. The BCCA datasets also were fitted to a 2-compartment, clearance-volume classical PK model. Model-derived PK parameters showed that about 35-48% of the matrine administered orally was absorbed by humans, which was consistent with the results of the in vitro Caco-2 cell transport study. The PBPK model also predicted that matrine was not metabolized significantly by humans confirming the results of the in vitro liver microsomal incubation studies. When the various CYP1A2, 2C19, 3A4, 2C9, and 2D6 probe substrates were incubated separately with human liver microsomes in the presence or absence of Acapha® extract, the metabolic rates of the CYP probes were not found to change significantly. Results of the present studies demonstrate that Caco-2 cell monolayer and PBPK model can provide important insights to the kinetics of Acapha® in humans. These scientific tools should be integrated with the herbal product development paradigm because they may render the development processes more rational and efficient.

Handbook Of Comparative Veterinary Pharmacokinetics And Residues Of Pesticides And Environmental Contaminants

Autor: Stephen F. Sundlof
Publisher: CRC Press
ISBN: 0849332133
File Size: 24,68 MB
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Residues of drugs and chemicals in edible tissues of food-producing animals are a major public health concern. Until now, information on applications of pharmacokinetic principles to drug and chemical residue avoidance has been spread throughout literature. For the first time, this handbook brings this information together in a convenient and concise volume. For easier reference, text is divided into three parts: physicochemical constants and chemical structures, legal tissue tolerances, and pharmacokinetic parameters derived from open literature. This is the only publication that offers all this information in a single source. For fast access, numerous tables present valuable pharmacokinetic data for drugs in serum, plasma, or blood and in other matrices. The authors include their own previously unpublished pharmacokinetic parameters, results of statistical analyses performed on time/concentration data tabulated in the primary sources. Helpful appendices contain FDA approved tolerances and action levels as well as chemical structures and physicochemical properties. This is an essential handbook for veterinarians, toxicologists, pharmacologists, animal scientists, food hygienists, and regulatory personnel involved in human food safety.