Bisphosphonates In Bone Disease

Autor: Herbert Fleisch
Publisher: Elsevier
ISBN: 9780080528113
File Size: 44,32 MB
Format: PDF, ePub
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This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, 4E, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs. * The revised fourth edition contains approximately 50% new material * Includes information on all the latest drugs

Osteogenesis Imperfecta

Autor: Peter H. Byers
Publisher: Academic Press
ISBN: 0123977894
File Size: 39,85 MB
Format: PDF
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Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI. Incorporates chapters and information on the ethical issues related to osteogenesis imperfecta (OI) as will the importance of nutrition in managing the OI child and the OI adult Offers new insights into the underlying mechanisms of collagen biochemistry as related to OI as well as a presentation of intracellular collagen processing and the expanded role of protein chaperones in OI Discusses the role of physical medicine and rehabilitation for OI patients and the current status of OI medical treatment as well as prospects for genetic engineering in the future Provides a unique overview for the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI

Bone Cancer

Autor: Dominique Heymann
Publisher: Academic Press
ISBN: 9780080953885
File Size: 14,17 MB
Format: PDF, ePub, Docs
Read: 543
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The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays

Bone Disease In Rheumatology

Autor: Michael J. Maricic
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781753012
File Size: 11,46 MB
Format: PDF, ePub, Docs
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Geared toward rheumatologists, this book examines the diagnosis, prevention, and treatment of bone loss in patients with inflammatory diseases. Drs. Maricic and Gluck—along with contributors from bone biology, diagnosis, imaging, biomarkers, and treatment—have developed a comprehensive, practical text on this specific aspect of rheumatology. Bone Disease in Rheumatology provides cutting-edge information on the pathophysiology of systemic and focal bone loss (erosions) in inflammatory disorders, the tools used to assess and measure bone loss, and the medications used in management of bone loss associated with rheumatic diseases. The book also discusses common and uncommon metabolic bone disorders, emphasizing state-of-the-art management techniques.

Osteoporosis An Issue Of Endocrinology And Metabolism Clinics E Book

Autor: Sol Epstein
Publisher: Elsevier Health Sciences
ISBN: 1455748447
File Size: 28,24 MB
Format: PDF
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This issue of Endocrinology and Metabolism Clinics provides a comprehensive review of osteoporosis written by the world's leading experts. Topics include new mechanistic insights into pathophysiology; bisphosphonates; combination therapy; atypical fractures; non-BP anti resorbers; anabolic therapies; calcium; the impact of Vitamin D on bones; extraskeletal effects of Vitamin D; glucocorticoid osteoporosis; relation to anorexia nervosa, coeliac disease, and diabetes; and male osteoporosis.

Myeloma Bone Disease

Autor: G. David Roodman
Publisher: Springer Science & Business Media
ISBN: 9781607615545
File Size: 12,25 MB
Format: PDF, ePub
Read: 2655
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This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.

Dental Management Of The Medically Compromised Patient E Book

Autor: James W. Little
Publisher: Elsevier Health Sciences
ISBN: 0323443958
File Size: 33,40 MB
Format: PDF, ePub, Docs
Read: 7772
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Learn how to provide dental care to any patient, regardless of existing medical conditions. Little and Falace’s Dental Management of the Medically Compromised Patient, 9th Edition, has been thoroughly revised to give you the information you need to assess common problems, and make safe and healthy dental management decisions. The new addition includes expanded coverage of women’s health issues and introduces a process for developing a medical-risk source. Also, each chapter features vivid illustrations and well-organized tables to give you in-depth details and overall summaries to help you get to the root of your future patients’ needs. Logical organization of conditions makes it easy for you to understand and follow the material as you prepare to treat patients. Standardized assessment process helps you to ascertain the severity and stability of common medical disorders. Dental management summary table summarizes important factors for consideration in the dental management of medically compromised patients. Over 400 color images provide a visual guide and highlight key information. Dental management box in each chapter allows you to locate key information for evaluating a medically compromised patient. NEW! Thoroughly revised content provides you with the most current, evidence-based information you need to make dental management decisions. NEW! Evidence-based process for creating a medical-risk score enables you to determine whether the benefit of treatment outweighs the risk of a complication. NEW! Expanded coverage of women’s health issues addresses issues specific to women that can impact dental management.

Management Of Urologic Malignancies

Autor: Freddie C. Hamdy
File Size: 56,44 MB
Format: PDF, Kindle
Read: 3900
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This is a highly accessible and practical guide to all urologic cancers. With a strong emphasis on best practice management choices, the book is ideal for the general urologist wishing to treat cancer patients with optimum effect. Each of the urologic cancers is discussed in depth, from incidence and etiology, diagnosis and imaging, through to staging and pathology, and finally multimodality management. Each management section is accompanied by a management algorithm for quick reference, the content of which is then expanded upon in text form for those seeking more detail. Comprehensive - covers all cancers encountered by urologists. Includes management algorithms - these summarise the expert's management plan Very well organised, accessible and user-friendly - supremely easy to navigate and use. Short, easy to read chapters with essential and basic knowledge including state-of-the-art methods of diagnosis and staging - complete - covers all issues the urologist needs to know about. Designed for the general urologist but written by the cancer specialist - expert guidance provided with a great author team. Easy and comprehensive coverage of the problem and good revision for examinations -perfect for trainees.

Metastatic Bone Disease

Autor: R. Lor Randall
Publisher: Springer
ISBN: 1461456622
File Size: 65,41 MB
Format: PDF, ePub
Read: 509
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Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and bio targeting. The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike.